AdresseThe Luxembourg Centre for Systems Biomedicine (LCSB) is an interdisciplinary research centre of the University of Luxembourg. We conduct fundamental and translational research in the field of Systems Biology and Biomedicine – in the lab, in the clinic and in silico – with a focus on neurodegenerative processes. The LCSB recruits talented scientists from various disciplines: computer scientists, mathematicians, biologists, chemists, engineers, physicists, and clinicians from more than 50 countries currently work at the LCSB. We excel because we are truly interdisciplinary and together we contribute to science and society.
The successful candidate will join theMolecular & Functional Neurobiology group, led by Prof. Anne Grünewald, which studies the genetic and non-genetic causes of neurodegeneration and neuroinflammation in Parkinson’s disease (PD). The group explores the contribution of intra- and intercellular mitochondrial signaling to these processes. Specifically, the R&D Specialist will support a project that investigates the α7 nicotinic acetylcholine receptor (α7nAChR) signaling in PD. For more information, please visit our website.
Your Role...
You will be responsible for the generation of the neuronal models to be used, which entails iPSC culture maintenance and differentiation into dopaminergic neurons. Furthermore, you will conduct lentiviral transductions to modulate the levels of key target proteins and will participate in subsequent functional and molecular studies.
To do so, you will have the following tasks and accountabilities:
- Cell culture activities (iPSC maintenance and differentiation into dopaminergic neurons)
- Lentiviral transductions to modulate the expression of key targets involved in α7nAChR signaling
- Standard molecular biology (Bradford, ELISA, Western blotting) and mitochondrial function (Seahorse technology, colorimetric dyes, enzyme kinetics with spectrophotometry etc.) assays
- Immunocytochemistry and high-content imaging analysis
- Real-time PCR, sequencing, cloning of plasmids and viral constructs
- Contribution to general laboratory organisation (ordering, overseeing of stocks, storage, preparation of solutions etc.)
What we expect from you…
- Master’s degree in biochemistry, molecular biology, or another similar life science-related discipline
- Strong background in cell and molecular biology
- Experience in cell culture, ideally with iPSC-derived cellular models, and neuronal differentiations
- Experience in microscopy and automated image analysis
- Fluency in R language for statistical analysis and data plotting will be considered an important asset
- Keen interest in investigating the Molecular basis of neurodegenerative and inflammatory diseases
- Strong motivation to contribute specific parts to larger projects
- Excellent organizational and management skills
- Excellent communication and teamwork skills
- Fluency in oral and written English is essential
Here’s what awaits you at the LCSB...
- Excellent work environment with state-of-the-art infrastructure, laboratory and administrative support
- Truly connected. We work together with hospitals and research institutes on a national and international level as well as industrial partners. Connection between science and society is very important to us. From our school lab – the Scienteens Lab – to the different outreach activities and collaborative partnerships with patient associations, we love to listen to society’s needs and share our passion for science
- Be part of a multicultural team. At the LCSB we have more than 50 nationalities. Throughout the year, we organise team-building events, networking activities and more
Find out more about us!
In Short...
- Contract type: Contrat à durée déterminée 10 Mois
- Work hours: Full Time 40.0 Heures par Semaine
- Location: Belval
- Internal title: Research and development specialist
- Job reference: UOL06239
How to apply...
Applications (in English) should contain the following documents:
- A detailed Curriculum vitae including a list of publications
- A cover letter that includes a brief description of previous research experience and the motivation for the specific advertised position
- Copies of diploma and transcripts
- Name and contact details of at least two referees
Early application is highly encouraged, as the applications will be processed upon reception. Please apply formally through the HR system. Applications by email will not be considered.
The University of Luxembourg embraces inclusion and diversity as key values. We are fully committed to removing any discriminatory barrier related to gender, and not only, in recruitment and career progression of our staff.
In return you will get…
- Multilingual and international character. Modern institution with a personal atmosphere. Staff coming from 90 countries. Member of the “University of the Greater Region” (UniGR)
- A modern and dynamic university. High-quality equipment. Close ties to the business world and to the Luxembourg labour market. A unique urban site with excellent infrastructure
- A partner for society and industry. Cooperation with European institutions, innovative companies, the Financial Centre and with numerous non-academic partners such as ministries, local governments, associations, NGOs …
- Find out more about the University
- Addresses, maps & routes to the various sites of the University
About the University of Luxembourg...
University of Luxembourg is an international research university with a distinctly multilingual and interdisciplinary character. The University was founded in 2003 and has more than 6,700 students and more than 2,000 employees from around the world. The University’s faculties and interdisciplinary centres focus on research in the areas of Computer Science and ICT Security, Materials Science, European and International Law, Finance and Financial Innovation, Education, Contemporary and Digital History. In addition, the University focuses on cross-disciplinary research in the areas of Data Modelling and Simulation as well as Health and System Biomedicine. Times Higher Education ranks the University of Luxembourg #3 worldwide for its “international outlook,” #20 in the Young University Ranking 2021 and among the top 250 universities worldwide.
For further information, please contact Prof Anne Grünewald (email address: anne.gruenewald@uni.lu). Use the job title and reference number mentioned above in the subject line of your email.
